| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ACAN |
| Gene ID: | 176 |
| Uniprot ID: | PGCA_HUMAN |
| Immunogen Region: | 420-656 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 420-575 of human Aggrecan (NP_037359.3). |
| Immunogen Sequence: | ATRPWGFPTPGLGPATAFTS EDLVVQVTAVPGQPHLPGGV VFHYRPGPTRYSLTFEEAQQ ACLRTGAVIASPEQLQAAYE AGYEQCDAGWLRDQTVRYPI VSPRTPCVGDKDSSPGVRTY GVRPSTETYDVYCFVDRLEG EVFFATRLEQFTFQEA |
| Tissue Specificity | Detected in fibroblasts (at protein level). Restricted to cartilage. |
| Post Translational Modifications | Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase. |
| Function | This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. |
| Protein Name | Aggrecan Core ProteinCartilage-Specific Proteoglycan Core ProteinCspcpChondroitin Sulfate Proteoglycan Core Protein 1Chondroitin Sulfate Proteoglycan 1 Cleaved Into - Aggrecan Core Protein 2 |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-2022854Reactome: R-HSA-2022857Reactome: R-HSA-3000178Reactome: R-HSA-3656225Reactome: R-HSA-3656243Reactome: R-HSA-3656244 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Aggrecan Core Protein antibodyAnti-Cartilage-Specific Proteoglycan Core Protein antibodyAnti-Cspcp antibodyAnti-Chondroitin Sulfate Proteoglycan Core Protein 1 antibodyAnti-Chondroitin Sulfate Proteoglycan 1 Cleaved Into - Aggrecan Core Protein 2 antibodyAnti-ACAN antibodyAnti-AGC1 antibodyAnti-CSPG1 antibodyAnti-MSK16 antibody |
Information sourced from Uniprot.org
