| Post Translational Modifications | Acetylated. Could occur at proximity of the cofactor-binding sites and reduce the catalytic activity. Could be deacetylated by SIRT3. |
| Function | Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains. |
| Protein Name | Medium-Chain Specific Acyl-Coa Dehydrogenase - MitochondrialMcadMedium Chain Acyl-Coa DehydrogenaseMcadh |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-77288Reactome: R-HSA-77346Reactome: R-HSA-77348 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Medium-Chain Specific Acyl-Coa Dehydrogenase - Mitochondrial antibodyAnti-Mcad antibodyAnti-Medium Chain Acyl-Coa Dehydrogenase antibodyAnti-Mcadh antibodyAnti-ACADM antibody |
Information sourced from Uniprot.org
