| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ABI1 (180-230) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ABI1 |
| Gene ID: |
10006 |
| Uniprot ID: |
ABI1_HUMAN |
| Immunogen Region: |
180-230 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 180-230 of human ABI1 (NP_001012770). |
| Immunogen Sequence: |
PMSGRGTLGRNTPYKTLEPV KPPTVPNDYMTSPARLGSQH SPGRTASLNQR |
| Tissue Specificity | Widely expressed, with highest expression in brain. |
| Post Translational Modifications | Phosphorylated on tyrosine residues after serum stimulation or induction by v-Abl. Seems to be phosphorylated at Tyr-53 by ABL1, required for nuclear but not for synaptic localization. |
| Function | May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. |
| Protein Name | Abl Interactor 1Abelson Interactor 1Abi-1Abl-Binding Protein 4Ablbp4Eps8 Sh3 Domain-Binding ProteinEps8-Binding ProteinNap1-Binding ProteinNap1bpSpectrin Sh3 Domain-Binding Protein 1E3b1 |
| Database Links | Reactome: R-HSA-2029482Reactome: R-HSA-4420097Reactome: R-HSA-5663213Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013423Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmNucleusCell ProjectionLamellipodiumFilopodiumGrowth ConePostsynaptic DensityCytoskeletonLocalized To Protruding Lamellipodia And Filopodia TipsAlso Localized To Neuronal Growth Cones And SynaptosomesMay Shuttle From The Postsynaptic Densities To The Nucleus |
| Alternative Antibody Names | Anti-Abl Interactor 1 antibodyAnti-Abelson Interactor 1 antibodyAnti-Abi-1 antibodyAnti-Abl-Binding Protein 4 antibodyAnti-Ablbp4 antibodyAnti-Eps8 Sh3 Domain-Binding Protein antibodyAnti-Eps8-Binding Protein antibodyAnti-Nap1-Binding Protein antibodyAnti-Nap1bp antibodyAnti-Spectrin Sh3 Domain-Binding Protein 1 antibodyAnti-E3b1 antibodyAnti-ABI1 antibodyAnti-SSH3BP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
