| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ABHD12 (110-250) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ABHD12 |
| Gene ID: |
26090 |
| Uniprot ID: |
ABD12_HUMAN |
| Immunogen Region: |
110-250 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 110-250 of human ABHD12 (NP_056415.1). |
| Immunogen Sequence: |
YFIDLKKPQDQGLNHTCNYY LQPEEDVTIGVWHTVPAVWW KNAQGKDQMWYEDALASSHP IILYLHGNAGTRGGDHRVEL YKVLSSLGYHVVTFDYRGWG DSVGTPSERGMTYDALHVFD WIKARSGDNPVYIWGHSLGT G |
| Post Translational Modifications | Glycosylated.glycosylation is required for optimal activity. |
| Function | Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes. Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system. Also able to hydrolyze oxidized phosphatidylserine.oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates.substrate specificity is likely due to improved catalysis and not improved substrate binding. |
| Protein Name | Lysophosphatidylserine Lipase Abhd122-Arachidonoylglycerol Hydrolase Abhd12Abhydrolase Domain-Containing Protein 12Habhd12Monoacylglycerol Lipase Abhd12Oxidized Phosphatidylserine Lipase Abhd12 |
| Database Links | Reactome: R-HSA-426048 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Lysophosphatidylserine Lipase Abhd12 antibodyAnti-2-Arachidonoylglycerol Hydrolase Abhd12 antibodyAnti-Abhydrolase Domain-Containing Protein 12 antibodyAnti-Habhd12 antibodyAnti-Monoacylglycerol Lipase Abhd12 antibodyAnti-Oxidized Phosphatidylserine Lipase Abhd12 antibodyAnti-ABHD12 antibodyAnti-C20orf22 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
