| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABHD12 |
| Gene ID: | 26090 |
| Uniprot ID: | ABD12_HUMAN |
| Immunogen Region: | 110-250 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 110-250 of human ABHD12 (NP_056415.1). |
| Immunogen Sequence: | YFIDLKKPQDQGLNHTCNYY LQPEEDVTIGVWHTVPAVWW KNAQGKDQMWYEDALASSHP IILYLHGNAGTRGGDHRVEL YKVLSSLGYHVVTFDYRGWG DSVGTPSERGMTYDALHVFD WIKARSGDNPVYIWGHSLGT G |
| Post Translational Modifications | Glycosylated.glycosylation is required for optimal activity. |
| Function | Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes. Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system. Also able to hydrolyze oxidized phosphatidylserine.oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates.substrate specificity is likely due to improved catalysis and not improved substrate binding. |
| Protein Name | Lysophosphatidylserine Lipase Abhd12 2-Arachidonoylglycerol Hydrolase Abhd12 Abhydrolase Domain-Containing Protein 12 Habhd12 Monoacylglycerol Lipase Abhd12 Oxidized Phosphatidylserine Lipase Abhd12 |
| Database Links | Reactome: R-HSA-426048 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Lysophosphatidylserine Lipase Abhd12 antibody Anti-2-Arachidonoylglycerol Hydrolase Abhd12 antibody Anti-Abhydrolase Domain-Containing Protein 12 antibody Anti-Habhd12 antibody Anti-Monoacylglycerol Lipase Abhd12 antibody Anti-Oxidized Phosphatidylserine Lipase Abhd12 antibody Anti-ABHD12 antibody Anti-C20orf22 antibody |
Information sourced from Uniprot.org