| Host: | Goat |
| Applications: | Pep-ELISA/FC/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-ABCD3 (Internal) is suitable for use in ELISA, Flow Cytometry and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000. IHC: In paraffin embedded Human Testis shows vesicular staining in Sertoli cells. Recommended concentration: 2.5-3.8µg/ml. FC:Flow cytometric analysis of A431 cells. Recommended concen |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | ABCD3 |
| Gene ID: | 5825 |
| Uniprot ID: | ABCD3_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_002849.1 |
| Specificity: | This antibody is expected to recognize one isoform (NP_002849.1) only. |
| Immunogen Sequence: | PDGREDQKRKGISD |
| Function | Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation. Has fatty acyl-CoA thioesterase and ATPase activities. Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes. Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation. |
| Protein Name | Atp-Binding Cassette Sub-Family D Member 3 70 Kda Peroxisomal Membrane Protein Pmp70 |
| Database Links | Reactome: R-HSA-1369062 Reactome: R-HSA-8980692 Reactome: R-HSA-9013106 Reactome: R-HSA-9603798 |
| Cellular Localisation | Peroxisome Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family D Member 3 antibody Anti-70 Kda Peroxisomal Membrane Protein antibody Anti-Pmp70 antibody Anti-ABCD3 antibody Anti-PMP70 antibody Anti-PXMP1 antibody |
Information sourced from Uniprot.org