| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABCC8 |
| Gene ID: | 6833 |
| Uniprot ID: | ABCC8_HUMAN |
| Immunogen Region: | 700-1000 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 700-1000 of human ABCC8 (NP_000343.2). |
| Immunogen Sequence: | TIRIPRGQLTMIVGQVGCGK SSLLLAALGEMQKVSGAVFW SSLPDSEIGEDPSPERETAT DLDIRKRGPVAYASQKPWLL NATVEENIIFESPFNKQRYK MVIEACSLQPDIDILPHGDQ TQIGERGINLSGGQRQRISV ARALYQHANVVFLDDPFSAL DIHLSDHLMQAGILELLRDD KRTVVLVTHKLQYLPHADWI IAMKDGTIQREGTLKDFQRS ECQLFEHWKTLMNRQDQEL |
| Function | Regulator subunit of pancreatic ATP-sensitive potassium channel (KATP), playing a major role in the regulation of insulin release. In pancreatic cells, it forms KATP channels with KCNJ11.KCNJ11 forms the channel pore while ABCC8 is required for activation and regulation. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 8Sulfonylurea Receptor 1 |
| Database Links | Reactome: R-HSA-1296025Reactome: R-HSA-422356Reactome: R-HSA-5683177 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 8 antibodyAnti-Sulfonylurea Receptor 1 antibodyAnti-ABCC8 antibodyAnti-HRINS antibodyAnti-SUR antibodyAnti-SUR1 antibody |
Information sourced from Uniprot.org
