| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ABCC5 (1-179) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ABCC5 |
| Gene ID: |
10057 |
| Uniprot ID: |
MRP5_HUMAN |
| Immunogen Region: |
1-179 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human ABCC5 (NP_005679.2). |
| Immunogen Sequence: |
MKDIDIGKEYIIPSPGYRSV RERTSTSGTHRDREDSKFRR TRPLECQDALETAARAEGLS LDASMHSQLRILDEEHPKGK YHHGLSALKPIRTTSKHQHP VDNAGLFSCMTFSWLSSLAR VAHKKGELSMEDVWSLSKHE SSDVNCRRLERLWQEELNEV GPDAASLRRVVWIFCRTRL |
| Tissue Specificity | Isoform 3: Predominant isoform in retinal pigment epithelium, bladder, and stomach. Ubiquitously expressed, but levels in brain and muscle are especially high. All isoforms are equally expressed in retina. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro). Acts also as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins. Confers resistance to the antiviral agent PMEA. Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated. Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway. May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 5Multi-Specific Organic Anion Transporter CMoat-CMultidrug Resistance-Associated Protein 5SmrpPabc11 |
| Database Links | Reactome: R-HSA-2142850Reactome: R-HSA-382556Reactome: R-HSA-9748787Reactome: R-HSA-9753281 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinGolgi Apparatus LumenEndosome MembraneCytoplasmic GranuleApical Cell MembraneIn Most CellsRoutes To The Basolateral Plasma MembraneBut In The Brain Capillary Endothelial Cells That Form The Blood-Brain BarrierResides In The Apical Membrane |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 5 antibodyAnti-Multi-Specific Organic Anion Transporter C antibodyAnti-Moat-C antibodyAnti-Multidrug Resistance-Associated Protein 5 antibodyAnti-Smrp antibodyAnti-Pabc11 antibodyAnti-ABCC5 antibodyAnti-MRP5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
