Anti-ABCB1 antibody (600-700 aa) [ABT252] (STJ197256)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenSynthesized peptide derived from the human MDR1 at the amino acid range 600-700
General Information
| Short Description | Mouse monoclonal anti-ATP-dependent translocase ABCB1 (600-700 aa) for use in IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | ABT252 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range | IHC-P 1:200-400WB 1:200-1000 |
| Formulation | Liquid in PBS pH7.2, 0.03% Proclin 300, with stabilizing protein. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ABCB1 |
| Gene ID | 5243 |
| Uniprot ID | MDR1_HUMAN |
| Immunogen | Synthesized peptide derived from the human MDR1 at the amino acid range 600-700 |
| Immunogen Region | 600-700 aa |
| Specificity | The antibody can specifically recognize human MDR1 protein. |
Additional Info
| Function | Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. |
| Protein Name | Atp-Dependent Translocase Abcb1Atp-Binding Cassette Sub-Family B Member 1Multidrug Resistance Protein 1P-Glycoprotein 1Phospholipid Transporter Abcb1Cd Antigen Cd243 |
| Database Links | Reactome: R-HSA-2161517Reactome: R-HSA-382556Reactome: R-HSA-9754706Reactome: R-HSA-9757110 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneCytoplasmAbcb1 Localization Is Influenced By C1orf115 Expression Levels (Plasma Membrane Versus Cytoplasm)Localized To The Apical Membrane Of Enterocytes |
| Alternative Antibody Names | Anti-Atp-Dependent Translocase Abcb1 antibodyAnti-Atp-Binding Cassette Sub-Family B Member 1 antibodyAnti-Multidrug Resistance Protein 1 antibodyAnti-P-Glycoprotein 1 antibodyAnti-Phospholipid Transporter Abcb1 antibodyAnti-Cd Antigen Cd243 antibodyAnti-ABCB1 antibodyAnti-MDR1 antibodyAnti-PGY1 antibody |
Information sourced from Uniprot.org