| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S0MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABCB1 |
| Gene ID: | 5243 |
| Uniprot ID: | MDR1_HUMAN |
| Immunogen Region: | 393-710 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 393-710 of human P Glycoprotein (P08183). |
| Immunogen Sequence: | EFRNVHFSYPSRKEVKILKG LNLKVQSGQTVALVGNSGCG KSTTVQLMQRLYDPTEGMVS VDGQDIRTINVRFLREIIGV VSQEPVLFATTIAENIRYGR ENVTMDEIEKAVKEANAYDF IMKLPHKFDTLVGERGAQLS GGQKQRIAIARALVRNPKIL LLDEATSALDTESEAVVQVA LDKARKGRTTIVIAHRLSTV RNADVIAGFDDGVIVEKGNH DELMKEKGIYFKLVTMQTA |
| Tissue Specificity | Expressed in small intestine. Expressed in liver, kidney and brain. |
| Function | Translocates drugs and phospholipids across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins. Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. |
| Protein Name | Atp-Dependent Translocase Abcb1 Atp-Binding Cassette Sub-Family B Member 1 Multidrug Resistance Protein 1 P-Glycoprotein 1 Phospholipid Transporter Abcb1 Cd Antigen Cd243 |
| Database Links | Reactome: R-HSA-2161517 Reactome: R-HSA-382556 Reactome: R-HSA-9754706 Reactome: R-HSA-9757110 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Apical Cell Membrane Cytoplasm Abcb1 Localization Is Influenced By C1orf115 Expression Levels (Plasma Membrane Versus Cytoplasm) Localized To The Apical Membrane Of Enterocytes |
| Alternative Antibody Names | Anti-Atp-Dependent Translocase Abcb1 antibody Anti-Atp-Binding Cassette Sub-Family B Member 1 antibody Anti-Multidrug Resistance Protein 1 antibody Anti-P-Glycoprotein 1 antibody Anti-Phospholipid Transporter Abcb1 antibody Anti-Cd Antigen Cd243 antibody Anti-ABCB1 antibody Anti-MDR1 antibody Anti-PGY1 antibody |
Information sourced from Uniprot.org