| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Abca8a |
| Gene ID: | 217258 |
| Uniprot ID: | ABC8A_MOUSE |
| Immunogen Region: | 690-828 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 690-828 of mouse ABCA8A (NP_694785.3). |
| Immunogen Sequence: | LKCAGSSLFLKKKWGIGYHL SLQLSETCVHERITSLVKQH IPDSKLSAESEGKLSYILPL ERTNKFPDLYRDLERSPDLG IENYGVSITTLTEVFLKLEG KSSIDQSDIGMTEDVQAGGA RSPERFAEVEQLVSLLNGR |
| Tissue Specificity | Expressed in lung, heart, liver, skeletal muscle and testis. Highly expressed in the liver, and is also abundant in heart and skeletal muscle. Highly expressed in heart. |
| Function | Mediates cholesterol and taurocholate efflux. Through the interaction with ABCA1 potentiates the cholesterol efflux to lipid-free APOA1, in turn regulates high-density lipoprotein cholesterol levels. |
| Protein Name | Abc-Type Organic Anion Transporter Abca8aAtp-Binding Cassette Sub-Family A Member 8a |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembranePredominantly Expressed On The Sinusoidal Plasma Membrane |
| Alternative Antibody Names | Anti-Abc-Type Organic Anion Transporter Abca8a antibodyAnti-Atp-Binding Cassette Sub-Family A Member 8a antibodyAnti-Abca8a antibody |
Information sourced from Uniprot.org