| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-ABC-type organic anion transporter ABCA8 (1151-1200 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000ELISA 1:40000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABCA8 |
| Gene ID: | 10351 |
| Uniprot ID: | ABCA8_HUMAN |
| Immunogen Region: | 1151-1200 aa |
| Specificity: | ABCA8 Polyclonal Antibody detects endogenous levels of ABCA8 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human ABCA8 at the amino acid range 1151-1200 |
| Function | Isoform 1: Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate. In vitro, also imports ochratoxin A. Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes. Isoform 3: Catalyzes ATP-dependent efflux of cholesterol and taurocholate. Interaction with ABCA1 potentiates cholesterol efflux to lipid-free APOA1, which regulates high-density lipoprotein cholesterol levels. |
| Protein Name | Abc-Type Organic Anion Transporter Abca8Atp-Binding Cassette Sub-Family A Member 8 |
| Database Links | Reactome: R-HSA-382556 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembranePredominantly Expressed On The Sinusoidal Plasma Membrane |
| Alternative Antibody Names | Anti-Abc-Type Organic Anion Transporter Abca8 antibodyAnti-Atp-Binding Cassette Sub-Family A Member 8 antibodyAnti-ABCA8 antibodyAnti-KIAA0822 antibody |
Information sourced from Uniprot.org