| Post Translational Modifications | Methylated at Gln-271 by N6AMT1. |
| Function | Probable lipid transporter that modulates cholesterol sequestration in the late endosome/lysosome by regulating the intracellular sphingolipid metabolism, in turn participates in cholesterol homeostasis (Probable). May alter the transbilayer distribution of ceramide in the intraluminal membrane lipid bilayer, favoring its retention in the outer leaflet that results in increased acid ceramidase activity in the late endosome/lysosome, facilitating ceramide deacylation to sphingosine leading to the sequestration of free cholesterol in lysosomes. In addition regulates amyloid-beta production either by activating a signaling pathway that regulates amyloid precursor protein transcription through the modulation of sphingolipid metabolism or through its role in gamma-secretase processing of APP. May play a role in myelin formation. |
| Protein Name | Atp-Binding Cassette Sub-Family A Member 2Atp-Binding Cassette Transporter 2Atp-Binding Cassette 2 |
| Database Links | Reactome: R-HSA-1369062 |
| Cellular Localisation | Endosome MembraneMulti-Pass Membrane ProteinLysosome MembraneForms DiscretePunctate Intracellular Vesicles |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family A Member 2 antibodyAnti-Atp-Binding Cassette Transporter 2 antibodyAnti-Atp-Binding Cassette 2 antibodyAnti-ABCA2 antibodyAnti-ABC2 antibodyAnti-KIAA1062 antibody |
Information sourced from Uniprot.org
