• Western blot analysis of lysates from HeLa cells, HepG2 cells, COLO205 cells, and HUVEC cells, using AATF Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using Che-1 Polyclonal Antibody

Anti-AATF antibody (10-59 aa) (STJ92259)

SKU:
STJ92259

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Protein AATF (10-59 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: AATF
Gene ID: 26574
Uniprot ID: AATF_HUMAN
Immunogen Region: 10-59 aa
Specificity: Che-1 Polyclonal Antibody detects endogenous levels of Che-1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human the amino acidTF at the amino acid range 10-59
Post Translational Modifications Hyperphosphorylated during the G1/S phase transition.
Function Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
Protein Name Protein Aatf
Apoptosis-Antagonizing Transcription Factor
Rb-Binding Protein Che-1
Database Links Reactome: R-HSA-193648
Cellular Localisation Nucleus
Nucleolus
Alternative Antibody Names Anti-Protein Aatf antibody
Anti-Apoptosis-Antagonizing Transcription Factor antibody
Anti-Rb-Binding Protein Che-1 antibody
Anti-AATF antibody
Anti-CHE1 antibody
Anti-DED antibody
Anti-HSPC277 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance