| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:3000 IF/ICC:1:100-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AAMP |
| Gene ID: | 14 |
| Uniprot ID: | AAMP_HUMAN |
| Immunogen Region: | 85-434 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 85-434 of human AAMP (NP_001078.2). |
| Immunogen Sequence: | VTFALHSASVFCVSLDPKTN TLAVTGGEDDKAFVWRLSDG ELLFECAGHKDSVTCAGFSH DSTLVATGDMSGLLKVWQVD TKEEVWSFEAGDLEWMEWHP RAPVLLAGTADGNTWMWKVP NGDCKTFQGPNCPATCGRVL PDGKRAVVGYEDGTIRIWDL KQGSPIHVLKGTEGHQGPLT CVAANQDGSLILTGSVDCQA KLVSATTGKVVGVFRPETVA SQPSLGEGEESESNSVESL |
| Tissue Specificity | Expressed in metastatic melanoma, liver, skin, kidney, heart, lung, lymph node, skeletal muscle and brain, and also in A2058 melanoma cells and activated T-cells (at protein level). Expressed in blood vessels. Strongly expressed in endothelial cells, cytotrophoblasts, and poorly differentiated. colon adenocarcinoma cells found in lymphatics. |
| Function | Plays a role in angiogenesis and cell migration. In smooth muscle cell migration, may act through the RhoA pathway. |
| Protein Name | Angio-Associated Migratory Cell Protein |
| Database Links | Reactome: R-HSA-168638 Reactome: R-HSA-177929 Reactome: R-HSA-194138 Reactome: R-HSA-428930 |
| Cellular Localisation | Cell Membrane Cytoplasm |
| Alternative Antibody Names | Anti-Angio-Associated Migratory Cell Protein antibody Anti-AAMP antibody |
Information sourced from Uniprot.org