| Host: | Goat |
| Applications: | Pep-ELISA/IF/FC |
| Reactivity: | Human/Mouse/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-AADACL1 (C-Term) is suitable for use in ELISA, Immunofluorescence and Flow Cytometry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:1000.WB: Preliminary experiments gave an approx 26-28kDa band in A431 cell lysates and in Human Hippocampus lysates after 1µg/ml antibody staining. This band was successfully blocked by incubati |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | NCEH1 |
| Gene ID: | 57552 |
| Uniprot ID: | NCEH1_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_065843.3; NP_001139748.2; NP_001139749.1 |
| Immunogen Sequence: | RTRNSYIKWLDQN |
| Post Translational Modifications | N-glycosylated. |
| Function | Hydrolyzes 2-acetyl monoalkylglycerol ether (1-O-alkyl-2-acetyl-sn-glycerol), the penultimate precursor of the pathway for de novo synthesis of platelet-activating factor. May be responsible for the hydrolysis of cholesterol esters (such as cholesteryl (9Z-octadecenoate)) in macrophages. Also involved in organ detoxification by hydrolyzing exogenous organophosphorus compounds. May contribute to cancer pathogenesis by promoting tumor cell migration. |
| Protein Name | Neutral Cholesterol Ester Hydrolase 1NcehAcetylalkylglycerol Acetylhydrolase2-Acetyl Mage HydrolaseArylacetamide Deacetylase-Like 1 |
| Database Links | Reactome: R-HSA-8964038 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinMicrosome |
| Alternative Antibody Names | Anti-Neutral Cholesterol Ester Hydrolase 1 antibodyAnti-Nceh antibodyAnti-Acetylalkylglycerol Acetylhydrolase antibodyAnti-2-Acetyl Mage Hydrolase antibodyAnti-Arylacetamide Deacetylase-Like 1 antibodyAnti-NCEH1 antibodyAnti-AADACL1 antibodyAnti-KIAA1363 antibody |
Information sourced from Uniprot.org