||WB, IHC, IF
||Human, Mouse, Rat
||FOR RESEARCH USE ONLY (RUO).
||Rabbit monoclonal antibody anti-A2M is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence.
||PBS containing 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
||WB 1:500-1:2000IHC 1:50-1:200IF 1:50-1:200
||Store in a freezer at-20°C and avoid freeze-thaw cycles.
||A synthesized peptide derived from human Alpha-2-Macroglobulin (Alpha-2-Macroglobulin (A2M) )
| Tissue Specificity || Secreted in plasma. |
| Function || Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. |
| Protein Name || Alpha-2-MacroglobulinAlpha-2-MC3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 |
| Database Links || Reactome: R-HSA-114608Reactome: R-HSA-140837Reactome: R-HSA-1474228Reactome: R-HSA-8963896 |
| Cellular Localisation || Secreted |
| Alternative Antibody Names || Anti-Alpha-2-Macroglobulin antibodyAnti-Alpha-2-M antibodyAnti-C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 5 antibodyAnti-A2M antibodyAnti-CPAMD5 antibodyAnti-FWP007 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance