• Western blot with Anti-5HT1A Antibody (STJ500000) of rat cortex at 1:250 dilution in buffer on a 14% SDS gel.

Anti-5HT1A antibody (200-250) (STJ500000)

SKU:
STJ500000-100

£441.50
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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:2, 500-1:5, 000
DB: 1:50, 000
ELISA: 1:50, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Htr1a
Gene ID: 24473
Uniprot ID: 5HT1A_RAT
Immunogen Region: 200-250
Immunogen: Synthetic peptide corresponding to amino acids within region 200-250 on rat 5-hydroxytryptamine receptor 1A protein.
Tissue Specificity Detected in hypothalamus, mesencephalon, amygdala, medulla, thalamus, septum and hippocampus.
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
Protein Name 5-Hydroxytryptamine Receptor 1a
5-Ht-1a
5-Ht1a
Serotonin Receptor 1a
Database Links Reactome: R-RNO-390666
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Dendrite
Alternative Antibody Names Anti-5-Hydroxytryptamine Receptor 1a antibody
Anti-5-Ht-1a antibody
Anti-5-Ht1a antibody
Anti-Serotonin Receptor 1a antibody
Anti-Htr1a antibody
Anti-5ht1a antibody

Information sourced from Uniprot.org

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