5HT1B Positive Control for STJ500005 peptide (STJ503614)

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STJ503614-5

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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: 5HT1B Positive Control for STJ500005 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:2, 500-1:5, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Htr1b
Gene ID: 15551
Uniprot ID: 5HT1B_MOUSE
Specificity: This is positive control is recommended for use in combination with 5HT1B antibody STJ500005.
Tissue Specificity Predominantly expressed in striatum and Purkinje cells.
Post Translational Modifications Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation. Palmitoylated.
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1B is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.
Peptide Name 5-Hydroxytryptamine Receptor 1b
5-Ht-1b
5-Ht1b
Serotonin Receptor 1b
Database Links Reactome: R-MMU-390666
Reactome: -MMU-418594
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Peptide Names 5-Hydroxytryptamine Receptor 1b protein
5-Ht-1b protein
5-Ht1b protein
Serotonin Receptor 1b protein
Htr1b protein
5ht1b protein

Information sourced from Uniprot.org

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