| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
5HT1B Blocking Peptide for STJ500004 is synthetically produced from the 160-260 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Htr1b |
| Gene ID: |
15551 |
| Uniprot ID: |
5HT1B_MOUSE |
| Immunogen Region: |
160-260 |
| Specificity: |
This blocking peptide is recommended for use in combination with 5HT1B antibody, STJ500004 |
| Immunogen: |
Synthetic peptide taken within amino acid region 160-260 on rat 5HT1B |
| Tissue Specificity | Predominantly expressed in striatum and Purkinje cells. |
| Post Translational Modifications | Phosphorylated. Palmitoylated. |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. |
| Peptide Name | 5-Hydroxytryptamine Receptor 1b5-Ht-1b5-Ht1bSerotonin Receptor 1b |
| Database Links | Reactome: R-MMU-390666Reactome: -MMU-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Peptide Names | 5-Hydroxytryptamine Receptor 1b protein5-Ht-1b protein5-Ht1b proteinSerotonin Receptor 1b proteinHtr1b protein5ht1b protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
