5HT1B Blocking Peptide for STJ500004 peptide (STJ503613)
General Information
| Short Description | 5HT1B Blocking Peptide for STJ500004 is synthetically produced from the 160-260 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Htr1b |
| Gene ID | 15551 |
| Uniprot ID | 5HT1B_MOUSE |
| Immunogen | Synthetic peptide taken within amino acid region 160-260 on rat 5HT1B |
| Immunogen Region | 160-260 |
| Specificity | This blocking peptide is recommended for use in combination with 5HT1B antibody, STJ500004 |
Additional Info
| Tissue Specificity | Predominantly expressed in striatum and Purkinje cells. |
| Post Translational Modifications | Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation. Palmitoylated. |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. HTR1B is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries. |
| Peptide Name | 5-Hydroxytryptamine Receptor 1b5-Ht-1b5-Ht1bSerotonin Receptor 1b |
| Database Links | Reactome: R-MMU-390666Reactome: -MMU-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Peptide Names | 5-Hydroxytryptamine Receptor 1b protein5-Ht-1b protein5-Ht1b proteinSerotonin Receptor 1b proteinHtr1b protein5ht1b protein |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about 5HT1B Blocking Peptide for STJ500004 peptide (STJ503613)
This is a blocking peptide intended for use in immunodepletion and immunocompetition experiments in combination with the 5HT1B antibody STJ500004. It is used to confirm antibody specificity by competitively inhibiting antibody binding to the target protein.
This blocking peptide is a synthetic peptide derived from within amino acid region 160 to 260 of rat 5HT1B (UniProt P28334).
This product is recommended for immunodepletion and immunocompetition applications only. It is intended for use as a specificity control in conjunction with STJ500004 and is for research use only.
This product is supplied in liquid form at 2.5 mg/ml in PBS, with the option to add up to 5% DMSO. Orders exceeding 1 mg can be supplied in lyophilized powder form or in a buffer of the customer's choice.
This blocking peptide should be stored at -20°C for long-term storage. Repeated freeze-thaw cycles should be avoided to maintain product integrity.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.