| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
ZMPSTE24 Positive Control for STJ503602 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: |
WB: 1:500 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
ZMPSTE24 |
| Gene ID: |
10269 |
| Uniprot ID: |
FACE1_HUMAN |
| Specificity: |
This is positive control is recommended for use in combination with ZMPSTE24 antibody STJ503602. |
| Tissue Specificity | Widely expressed. High levels in kidney, prostate, testis and ovary. |
| Function | Transmembrane metalloprotease whose catalytic activity is critical for processing lamin A/LMNA on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulum. Proteolytically removes the C-terminal three residues of farnesylated proteins. Plays also an antiviral role independently of its protease activity by restricting enveloped RNA and DNA viruses, including influenza A, Zika, Ebola, Sindbis, vesicular stomatitis, cowpox, and vaccinia. Mechanistically, controls IFITM antiviral pathway to hinder viruses from breaching the endosomal barrier by modulating membrane fluidity. |
| Peptide Name | Caax Prenyl Protease 1 HomologFarnesylated Proteins-Converting Enzyme 1Face-1Prenyl Protein-Specific Endoprotease 1Zinc Metalloproteinase Ste24 Homolog |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinNucleus Inner MembraneEarly Endosome MembraneLate Endosome Membrane |
| Alternative Peptide Names | Caax Prenyl Protease 1 Homolog proteinFarnesylated Proteins-Converting Enzyme 1 proteinFace-1 proteinPrenyl Protein-Specific Endoprotease 1 proteinZinc Metalloproteinase Ste24 Homolog proteinZMPSTE24 proteinFACE1 proteinSTE24 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
