| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | WWOX3 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:500 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | WWOX |
| Gene ID: | 51741 |
| Uniprot ID: | WWOX_HUMAN |
| Tissue Specificity | Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines. |
| Post Translational Modifications | Phosphorylated upon genotoxic stress. Phosphorylation of Tyr-33 regulates interaction with TP53, TP73 and MAPK8. May also regulate proapoptotic activity. Phosphorylation by TNK2 is associated with polyubiquitination and degradation. Ubiquitinated when phosphorylated by TNK2, leading to its degradation. |
| Function | Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. |
| Peptide Name | Ww Domain-Containing Oxidoreductase Fragile Site Fra16d Oxidoreductase Short Chain Dehydrogenase/Reductase Family 41c Member 1 |
| Database Links | Reactome: R-HSA-1251985 Reactome: R-HSA-8866904 Reactome: R-HSA-8866907 |
| Cellular Localisation | Cytoplasm Nucleus Mitochondrion Golgi Apparatus Lysosome Partially Localizes To The Mitochondria Translocates To The Nucleus Upon Genotoxic Stress Or Tnf Stimulation Translocates To The Nucleus In Response To Tgfb1 Isoform 5 And Isoform 6 May Localize In The Nucleus Localized To The Lysosome Probably Upon Binding To Vopp1 |
| Alternative Peptide Names | Ww Domain-Containing Oxidoreductase protein Fragile Site Fra16d Oxidoreductase protein Short Chain Dehydrogenase/Reductase Family 41c Member 1 protein WWOX protein FOR protein SDR41C1 protein WOX1 protein |
Information sourced from Uniprot.org