| Function | Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. |
| Peptide Name | Vacuolar Protein-Sorting-Associated Protein 36Ell-Associated Protein Of 45 KdaEscrt-Ii Complex Subunit Vps36 |
| Database Links | Reactome: R-HSA-917729Reactome: R-HSA-9610379 |
| Cellular Localisation | CytoplasmEndosomeLate EndosomeMembraneNucleusColocalizes With Ubiquitinated Proteins On Late EndosomesRecruited To The Endosome Membrane To Participate In Vesicle Formation |
| Alternative Peptide Names | Vacuolar Protein-Sorting-Associated Protein 36 proteinEll-Associated Protein Of 45 Kda proteinEscrt-Ii Complex Subunit Vps36 proteinVPS36 proteinC13orf9 proteinEAP45 proteinCGI-145 protein |
Information sourced from Uniprot.org
