ULK1 Blocking Peptide for STJ503461 peptide (STJ505053)

SKU:
STJ505053-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: ULK1 Blocking Peptide for STJ503461 is synthetically produced from the 1000-1050 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: ULK1
Gene ID: 8408
Uniprot ID: ULK1_HUMAN
Immunogen Region: 1000-1050
Specificity: This blocking peptide is recommended for use in combination with ULK1 antibody, STJ503461
Immunogen: Synthetic peptide taken within amino acid region 1000-1050 on mouse ULK1 protein.
Tissue Specificity Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.
Post Translational Modifications Autophosphorylated. Phosphorylated under nutrient-rich conditions.dephosphorylated during starvation or following treatment with rapamycin. Under nutrient sufficiency, phosphorylated by MTOR/mTOR, disrupting the interaction with AMPK and preventing activation of ULK1. In response to nutrient limitation, phosphorylated and activated by AMPK, leading to activate autophagy. Ubiquitinated via 'Lys-63'-linkage by a complex composed of AMBRA1 and TRAF6 following autophagy induction, promoting ULK1 stability and kinase activity. Deubiquitinated by USP20.leading to ULK1 stability and autophagy initiation. Acetylated by KAT5/TIP60 under autophagy induction, promoting protein kinase activity.
Function Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR.however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy. Phosphorylates FLCN, promoting autophagy. Phosphorylates AMBRA1 in response to autophagy induction, releasing AMBRA1 from the cytoskeletal docking site to induce autophagosome nucleation. Phosphorylates ATG4B, leading to inhibit autophagy by decreasing both proteolytic activation and delipidation activities of ATG4B.
Peptide Name Serine/Threonine-Protein Kinase Ulk1
Autophagy-Related Protein 1 Homolog
Atg1
Hatg1
Unc-51-Like Kinase 1
Database Links Reactome: R-HSA-1632852
Reactome: R-HSA-5357905
Reactome: R-HSA-8854214
Reactome: R-HSA-8876198
Reactome: R-HSA-8934903
Cellular Localisation Cytoplasm
Cytosol
Preautophagosomal Structure
Under Starvation Conditions
Is Localized To Puncate Structures Primarily Representing The Isolation Membrane That Sequesters A Portion Of The Cytoplasm Resulting In The Formation Of An Autophagosome
Alternative Peptide Names Serine/Threonine-Protein Kinase Ulk1 protein
Autophagy-Related Protein 1 Homolog protein
Atg1 protein
Hatg1 protein
Unc-51-Like Kinase 1 protein
ULK1 protein
KIAA0722 protein

Information sourced from Uniprot.org

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