| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
TPCN1 Blocking Peptide for STJ503363 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
TPCN1 |
| Gene ID: |
53373 |
| Uniprot ID: |
TPC1_HUMAN |
| Specificity: |
This blocking peptide is recommended for use in combination with TPCN1 antibody, STJ503363 |
| Immunogen: |
Synthetic peptide taken within TMD7 and TMD8 on human TPC1 protein. |
| Tissue Specificity | Highest expression found in the heart and kidney, and lowest expression found in the spleen. |
| Post Translational Modifications | N-glycosylated. |
| Function | Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles. Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (Probable). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (Probable). Required for mTOR-dependent nutrient sensing (Probable). (Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm. |
| Peptide Name | Two Pore Channel Protein 1Two Pore Calcium Channel Protein 1Voltage-Dependent Calcium Channel Protein Tpc1 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Lysosome MembraneMulti-Pass Membrane ProteinEndosome MembraneEarly Endosome MembraneRecycling Endosome Membrane |
| Alternative Peptide Names | Two Pore Channel Protein 1 proteinTwo Pore Calcium Channel Protein 1 proteinVoltage-Dependent Calcium Channel Protein Tpc1 proteinTPCN1 proteinKIAA1169 proteinTPC1 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
