| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
TLR5 Blocking Peptide for STJ503302 is synthetically produced from the 195-225 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
TLR5 |
| Gene ID: |
7100 |
| Uniprot ID: |
TLR5_HUMAN |
| Immunogen Region: |
195-225 |
| Specificity: |
This blocking peptide is recommended for use in combination with TLR5 antibody, STJ503302 |
| Immunogen: |
Synthetic peptide taken within amino acid region 195-225 on human TLR5 protein. |
| Tissue Specificity | Highly expressed on the basolateral surface of intestinal epithelia. Expressed also in other cells such as lung epithelial cells. |
| Post Translational Modifications | Phosphorylated at Ser-805 by PKD/PRKD1.phosphorylation induces the production of inflammatory cytokines. Phosphorylated at Tyr-798 upon flagellin binding.required for signaling. |
| Function | Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response. Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota. Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response. Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life. |
| Peptide Name | Toll-Like Receptor 5Toll/Interleukin-1 Receptor-Like Protein 3 |
| Database Links | Reactome: R-HSA-168176Reactome: R-HSA-5602680Reactome: R-HSA-5603037Reactome: R-HSA-975871 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Peptide Names | Toll-Like Receptor 5 proteinToll/Interleukin-1 Receptor-Like Protein 3 proteinTLR5 proteinTIL3 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
