| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Syncytin 2 Blocking Peptide for STJ503173 is synthetically produced from the 380-430 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Synb |
| Gene ID: |
239167 |
| Uniprot ID: |
SYNB_MOUSE |
| Immunogen Region: |
380-430 |
| Specificity: |
This blocking peptide is recommended for use in combination with Syncytin 2 antibody, STJ503173 |
| Immunogen: |
Synthetic peptide taken within amino acid region 380-430 on mouse Envelope glycoprotein syncytin-B protein. |
| Tissue Specificity | Highly expressed in placenta where it localizes to syncytiotrophoblasts of the labyrinthine zona. Specifically localizes to syncytiotrophoblast layer II (SynT-II). Also detected at very low levels in ovary. |
| Post Translational Modifications | Synthesized as an inactive precursor that is heavily N-glycosylated and processed likely by furin in the Golgi to yield the mature SU and TM proteins. The cleavage site between SU and TM requires the minimal sequence KR-X-KR-R. The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion. |
| Function | This endogenous retroviral envelope protein has retained its original fusogenic properties. Together with Syna, participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. Synb is specifically involved in formation of syncytiotrophoblast layer II (SynT-II). Promotes myoblast fusion, and may play a role in regeneration of damaged muscle tissue in males. May have immunosuppressive activity. |
| Peptide Name | Syncytin-B Cleaved Into - Surface ProteinSu - Transmembrane ProteinTm |
| Cellular Localisation | Surface Protein: Cell MembranePeripheral Membrane ProteinThe Surface Protein Is Not Anchored To The MembraneBut Localizes To The Extracellular Surface Through Its Binding To TmTransmembrane Protein: Cell MembraneSingle-Pass Membrane Protein |
| Alternative Peptide Names | Syncytin-B Cleaved Into - Surface Protein proteinSu - Transmembrane Protein proteinTm proteinSynb protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
