| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Stra6 Blocking Peptide for STJ503149 is synthetically produced from the 200-300 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Stra6 |
| Gene ID: |
20897 |
| Uniprot ID: |
STRA6_MOUSE |
| Immunogen Region: |
200-300 |
| Specificity: |
This blocking peptide is recommended for use in combination with Stra6 antibody, STJ503149 |
| Immunogen: |
Synthetic peptide taken within third large intra cytoplasmic loop within amino acid region 200-300 on rat Stra6 protein. |
| Tissue Specificity | Widely expressed in the embryo. Detected in adult in the retinal pigment epithelium in the eye. In the adult, is highly expressed in cells that compose blood-organ barriers in the brain (choroid plexus and the brain microvascular), in testis (the basal layer of the seminiferous epithelium), in the yolk sac, and in the chorioallantoic placenta. Detected in white adipose tissue and skeletal muscle, but not in liver (at protein level). Widely expressed in adult, with high expression levels in the eye. Detected in brain, cerebellum, testis, pituitary, pancreas, kidney, spleen, and female genital tract.and at very low levels in heart and lung. Not detected in liver. |
| Post Translational Modifications | Phosphorylated on tyrosine residues in response to RBP4 binding. Phosphorylation requires the presence of LRAT, suggesting it may be triggered by the uptake of retinol that is then metabolized within the cell to retinoids that function as signaling molecules. |
| Function | Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1. Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A. Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin. Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid and 11-cis-retinal. STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency. Does not transport retinoic acid. |
| Peptide Name | Receptor For Retinol Uptake Stra6Retinoic Acid-Responsive ProteinRetinol-Binding Protein Receptor Stra6Stimulated By Retinoic Acid Gene 6 Protein |
| Database Links | Reactome: R-MMU-2453902 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinIn The Retinal Pigment Epithelium Localizes To The Basolateral MembranePlasma Membrane Of The Basal Pole Of Sertoli CellsAbsent In Plasma Membrane Of Neighboring Spermatogonia |
| Alternative Peptide Names | Receptor For Retinol Uptake Stra6 proteinRetinoic Acid-Responsive Protein proteinRetinol-Binding Protein Receptor Stra6 proteinStimulated By Retinoic Acid Gene 6 Protein proteinStra6 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
