| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
SKOR1 Positive Control for STJ507768 is synthetically produced from the N-Term sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Htr1a |
| Gene ID: |
24473 |
| Uniprot ID: |
5HT1A_RAT |
| Immunogen Region: |
N-Term |
| Specificity: |
This is positive control is recommended for use in combination with SKOR1 antibody STJ507768. |
| Immunogen: |
Synthetic peptide corresponding to amino acids within region 650-700 on human SKOR1 protein. |
| Function | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli. |
| Peptide Name | 5-Hydroxytryptamine Receptor 1a5-Ht-1a5-Ht1aSerotonin Receptor 1a |
| Database Links | Reactome: R-RNO-390666 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionDendrite |
| Alternative Peptide Names | 5-Hydroxytryptamine Receptor 1a protein5-Ht-1a protein5-Ht1a proteinSerotonin Receptor 1a proteinHtr1a protein5ht1a protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
