SKOR1 Positive Control for STJ507768 peptide (STJ507770)

SKU:
STJ507770-5

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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: SKOR1 Positive Control for STJ507768 is synthetically produced from the N-Term sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Htr1a
Gene ID: 24473
Uniprot ID: 5HT1A_RAT
Immunogen Region: N-Term
Specificity: This is positive control is recommended for use in combination with SKOR1 antibody STJ507768.
Immunogen: Synthetic peptide corresponding to amino acids within region 650-700 on human SKOR1 protein.
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.
Peptide Name 5-Hydroxytryptamine Receptor 1a
5-Ht-1a
5-Ht1a
Serotonin Receptor 1a
Database Links Reactome: R-RNO-390666
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Dendrite
Alternative Peptide Names 5-Hydroxytryptamine Receptor 1a protein
5-Ht-1a protein
5-Ht1a protein
Serotonin Receptor 1a protein
Htr1a protein
5ht1a protein

Information sourced from Uniprot.org

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