| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
SIRT5 Blocking Peptide for STJ503039 is synthetically produced from the 260-310 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Sirt5 |
| Gene ID: |
306840 |
| Uniprot ID: |
SIR5_RAT |
| Immunogen Region: |
260-310 |
| Specificity: |
This blocking peptide is recommended for use in combination with SIRT5 antibody, STJ503039 |
| Immunogen: |
Synthetic peptide taken within amino acid region 260-310 on rat Sirtuin 5 protein. |
| Function | NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Activates SHMT2 by mediating its desuccinylation. Modulates ketogenesis through the desuccinylation and activation of HMGCS2. Has weak NAD-dependent protein deacetylase activity.however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX. |
| Peptide Name | Nad-Dependent Protein Deacylase Sirtuin-5 - MitochondrialRegulatory Protein Sir2 Homolog 5Sir2-Like Protein 5 |
| Database Links | Reactome: R-RNO-2151201 |
| Cellular Localisation | MitochondrionCytoplasmCytosolNucleusMainly MitochondrialAlso Present ExtramitochondriallyWith A Fraction Present In The Cytosol And Very Small Amounts Also Detected In The Nucleus |
| Alternative Peptide Names | Nad-Dependent Protein Deacylase Sirtuin-5 - Mitochondrial proteinRegulatory Protein Sir2 Homolog 5 proteinSir2-Like Protein 5 proteinSirt5 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
