SHANK3 Blocking Peptide for STJ502996 is synthetically produced from the 1600-1650 sequence and is suitable for use in western blot applications.
Applications
Immunodepletion/Immunocompetition
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Formulation
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction
Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Synthetic peptide taken within amino acid region 1600-1650 on mouse SH3 and multiple ankyrin repeat domains protein 3.
Immunogen Region
1600-1650
Specificity
This blocking peptide is recommended for use in combination with SHANK3 antibody, STJ502996
Additional Info
Tissue Specificity
In brain, highly expressed in striatum, thalamus, hippocampus and granule cells of the cerebellum.
Function
Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.
Peptide Name
Sh3 And Multiple Ankyrin Repeat Domains Protein 3Shank3Proline-Rich Synapse-Associated Protein 2Prosap2Spank-2
CytoplasmSynapsePostsynaptic DensityCell ProjectionDendritic SpineIn Neuronal CellsExtends Into The Region Subjacent To The Postsynaptic Density (Psd)
Alternative Peptide Names
Sh3 And Multiple Ankyrin Repeat Domains Protein 3 proteinShank3 proteinProline-Rich Synapse-Associated Protein 2 proteinProsap2 proteinSpank-2 proteinShank3 proteinKiaa1650 proteinProsap2 protein
