| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
SGK2 Blocking Peptide for STJ502982 is synthetically produced from the 377-427 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
SGK2 |
| Gene ID: |
10110 |
| Uniprot ID: |
SGK2_HUMAN |
| Immunogen Region: |
377-427 |
| Specificity: |
This blocking peptide is recommended for use in combination with SGK2 antibody, STJ502982 |
| Immunogen: |
Synthetic peptide taken within amino acid region 377-427 on human Sgk2 protein. |
| Tissue Specificity | Highly expressed in liver, kidney and pancreas, and at lower levels in brain. |
| Post Translational Modifications | Activated by phosphorylation on Ser-356 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-193. |
| Function | Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. |
| Peptide Name | Serine/Threonine-Protein Kinase Sgk2Serum/Glucocorticoid-Regulated Kinase 2 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Peptide Names | Serine/Threonine-Protein Kinase Sgk2 proteinSerum/Glucocorticoid-Regulated Kinase 2 proteinSGK2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
