Tissue Specificity | Highly expressed in the retinal pigment epithelium (RPE) and pancreas. Weak expression in heart, liver and muscle. |
Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP5 may be involved in determining the polarity of photoreceptor, and perhaps, other cells in the retina. |
Peptide Name | Secreted Frizzled-Related Protein 5Sfrp-5Frizzled-Related Protein 1bFrp-1bSecreted Apoptosis-Related Protein 3Sarp-3 |
Cellular Localisation | Secreted |
Alternative Peptide Names | Secreted Frizzled-Related Protein 5 proteinSfrp-5 proteinFrizzled-Related Protein 1b proteinFrp-1b proteinSecreted Apoptosis-Related Protein 3 proteinSarp-3 proteinSFRP5 proteinFRP1B proteinSARP3 protein |
Information sourced from Uniprot.org