| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | SESN1 Blocking Peptide for STJ502954 is synthetically produced from the 1-50 sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | SESN1 |
| Gene ID: | 27244 |
| Uniprot ID: | SESN1_HUMAN |
| Immunogen Region: | 1-50 |
| Specificity: | This blocking peptide is recommended for use in combination with SESN1 antibody, STJ502954 |
| Immunogen: | Synthetic peptide taken within amino acid region 1-50 on human SESN1 protein. |
| Tissue Specificity | Widely expressed. |
| Function | Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed. |
| Peptide Name | Sestrin-1 P53-Regulated Protein Pa26 |
| Database Links | Reactome: R-HSA-5628897 Reactome: R-HSA-9639288 Reactome: R-HSA-9755511 |
| Cellular Localisation | Nucleus Cytoplasm |
| Alternative Peptide Names | Sestrin-1 protein P53-Regulated Protein Pa26 protein SESN1 protein PA26 protein SEST1 protein |
Information sourced from Uniprot.org