| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
RIC8A Blocking Peptide for STJ502777 is synthetically produced from the 500-535 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
RIC8A |
| Gene ID: |
60626 |
| Uniprot ID: |
RIC8A_HUMAN |
| Immunogen Region: |
500-535 |
| Specificity: |
This blocking peptide is recommended for use in combination with RIC8A antibody, STJ502777 |
| Immunogen: |
Synthetic peptide taken within amino acids 500-535 on RIC8A protein |
| Function | Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation. |
| Peptide Name | Synembryn-AProtein Ric-8a |
| Cellular Localisation | CytoplasmCell MembraneColocalizes With Rgs14 In Ca2 Hippocampal NeuronsColocalizes With Gnai1 And Rgs14 At The Plasma Membrane |
| Alternative Peptide Names | Synembryn-A proteinProtein Ric-8a proteinRIC8A protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
