RIC8A Blocking Peptide for STJ502777 peptide (STJ504854)

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STJ504854-250
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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : RIC8A Blocking Peptide for STJ502777 is synthetically produced from the 500-535 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: RIC8A
Gene ID: 60626
Uniprot ID: RIC8A_HUMAN
Immunogen Region: 500-535
Specificity: This blocking peptide is recommended for use in combination with RIC8A antibody, STJ502777
Immunogen: Synthetic peptide taken within amino acids 500-535 on RIC8A protein
Post Translational Modifications Phosphorylated at Ser-436 and Thr-441 by CK2, stabilizing its interface with G alpha proteins.
Function Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ. Does not fold G(s) G-alpha proteins GNAS nor GNAL. Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
Peptide Name Chaperone Ric-8a
Synembryn-A
Cellular Localisation Cytoplasm
Cell Cortex
Alternative Peptide Names Chaperone Ric-8a protein
Synembryn-A protein
RIC8A protein

Information sourced from Uniprot.org

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