Rat VEGF-A/VEGF164 protein (Recombinant) (C-His) (STJP001318)

Rat VEGF-A/VEGF164 protein (Recombinant) (C-His) (STJP001318)

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STJP001318
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity: 1.Measured by its binding ability in a functional ELISA. Immobilized Rat VEGF164 at 1 Mu g/mL (100 Mu L/well) can bind Human KDR with a linear range of 0.03-3.6 ng/mL.|2.Measured in a cell proliferation assay using human umbilical vein endothelial ce
Gene Symbol: Vegfa
Gene ID: 83785
Uniprot ID: VEGFA_RAT
Immunogen: Recombinant Rat VEGF-A/VEGF164 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala27-Arg190) of Rat VEGFA (Accession #NP_001274037.1) fused with an 6×His tag at the C-terminus.
Immunogen Sequence: APTTEGEQKAHEVVKFMDVY QRSYCRPIETLVDIFQEYPD EIEYIFKPSCVPLMRCAGCC NDEALECVPTSESNVTMQIM RIKPHQSQHIGEMSFLQHSR CECRPKKDRTKPENHCEPCS ERRKHLFVQDPQTCKCSCKN TDSRCKARQLELNERTCRCD KPRR
Function Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Also binds the DEAR/FBXW7-AS1 receptor.
Protein Name Vascular Endothelial Growth Factor A
Vegf-A
Vascular Permeability Factor
Vpf
Database Links Reactome: R-RNO-114608
Reactome: -RNO-194313
Reactome: -RNO-195399
Reactome: -RNO-4420097
Reactome: -RNO-5218921
Cellular Localisation Secreted
Vegf-A120 Is Acidic And Freely Secreted
Vegf-A164 Is More Basic
Has Heparin-Binding Properties And
Although A Significant Proportion Remains Cell-Associated
Most Is Freely Secreted
Vegf-A188 Is Very Basic
It Is Cell-Associated After Secretion And Is Bound Avidly By Heparin And The Extracellular Matrix
Although It May Be Released As A Soluble Form By Heparin
Heparinase Or Plasmin
Alternative Protein Names Vascular Endothelial Growth Factor A protein
Vegf-A protein
Vascular Permeability Factor protein
Vpf protein
Vegfa protein
Vegf protein

Information sourced from Uniprot.org

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