• Rat VEGF-A/VEGF164 protein (Recombinant) (C-His) (STJP001318)
  • Rat VEGF-A/VEGF164 protein (Recombinant) (C-His) (STJP001318)
  • Rat VEGF-A/VEGF164 protein (Recombinant) (C-His) (STJP001318)
  • Rat VEGF-A/VEGF164 protein (Recombinant) (C-His) (STJP001318)
  • Rat VEGF-A/VEGF164 protein (Recombinant) (C-His) (STJP001318)
  • Rat VEGF-A/VEGF164 protein (Recombinant) (C-His) (STJP001318)

Rat VEGF-A/VEGF164 protein (Recombinant) (C-His) (STJP001318)

SKU:
STJP001318

£76.50 - £248.50
Current Stock:
Host: HEK293 cells
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Rat VEGF-A/VEGF164-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Rat VEGF164 at 1 Mu g/mL (100 Mu L/well) can bind Human KDR with a linear range of 0.03-3.6 ng/mL.2. Measured in a cell proliferation assay using human umbilical vein endothelial cell
Gene Symbol: Vegfa
Gene ID: 83785
Uniprot ID: VEGFA_RAT
Immunogen: Recombinant Rat VEGF-A/VEGF164 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala27-Arg190) of Rat VEGFA (Accession #NP_001274037.1) fused with an 6×His tag at the C-terminus.
Function Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. May play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. Also binds the DEAR/FBXW7-AS1 receptor.
Protein Name Vascular Endothelial Growth Factor A
Vegf-A
Vascular Permeability Factor
Vpf
Database Links Reactome: R-RNO-114608
Reactome: -RNO-194313
Reactome: -RNO-195399
Reactome: -RNO-4420097
Reactome: -RNO-5218921
Cellular Localisation Secreted
Vegf-A120 Is Acidic And Freely Secreted
Vegf-A164 Is More Basic
Has Heparin-Binding Properties And
Although A Significant Proportion Remains Cell-Associated
Most Is Freely Secreted
Vegf-A188 Is Very Basic
It Is Cell-Associated After Secretion And Is Bound Avidly By Heparin And The Extracellular Matrix
Although It May Be Released As A Soluble Form By Heparin
Heparinase Or Plasmin
Alternative Protein Names Vascular Endothelial Growth Factor A protein
Vegf-A protein
Vascular Permeability Factor protein
Vpf protein
Vegfa protein
Vegf protein

Information sourced from Uniprot.org

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