Rat SOCS2 (Suppressors Of Cytokine Signaling 2) Sandwich ELISA Kit Ready-To-Use Kit (STJE0018648)
SPECIFICATIONS
General Information
| Short Description | This SOCS2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Rat |
| Sensitivity | 0.124ng/mL |
| Detection Limit | 0.312-20ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | Socs2 |
| Gene ID | 84607 |
| Uniprot ID | SOCS2_RAT |
| Immunogen Region | Ready-To-Use |
| Sample Type | tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | |
| Post Translational Modifications | Ubiquitinated.mediated by AREL1 and leading to its subsequent proteasomal degradation. Ubiquitination is dependent on its phosphorylation at Ser-52, by PKC. Ubiquitination is stimulated by LPS. Phosphorylation at Ser-52 by PKC facilitates its ubiquitination and proteasomal degradation. |
| Function | Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2. The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR. |
| Protein Name | Suppressor Of Cytokine Signaling 2Socs-2Cytokine-Inducible Sh2 Protein 2 |
| Database Links | Reactome: R-RNO-8951664 |
| Cellular Localisation | Cytoplasm |
| Alternative ELISA Names | Suppressor Of Cytokine Signaling 2 ELISA kitSocs-2 ELISA kitCytokine-Inducible Sh2 Protein 2 ELISA kitSocs2 ELISA kitCish2 ELISA kit |
| output |
Information sourced from Uniprot.org