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Post Translational Modifications | |
Function | Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli. Plays a key role in inflammation response, fever and pain. Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively. |
Protein Name | Prostaglandin E SynthaseMpges-1Glutathione Peroxidase PtgesGlutathione Transferase PtgesInducible Prostaglandin E SynthaseMicrosomal Prostaglandin E Synthase 1 |
Database Links | Reactome: R-RNO-2162123 |
Cellular Localisation | MembraneMulti-Pass Membrane ProteinCytoplasmPerinuclear RegionColocalizes With Ptgs1/Cox-1 And Ptgs2/Cox-2 In The Perinuclear Compartment |
Alternative ELISA Names | Prostaglandin E Synthase ELISA kitMpges-1 ELISA kitGlutathione Peroxidase Ptges ELISA kitGlutathione Transferase Ptges ELISA kitInducible Prostaglandin E Synthase ELISA kitMicrosomal Prostaglandin E Synthase 1 ELISA kitPtges ELISA kitPges ELISA kitPig12 ELISA kit |
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Information sourced from Uniprot.org