Tissue Specificity | |
Post Translational Modifications | Phosphorylated on serine residues. |
Function | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria. |
Protein Name | Presenilin-2Ps-2 Cleaved Into - Presenilin-2 Ntf Subunit - Presenilin-2 Ctf Subunit |
Database Links | Reactome: R-RNO-1251985Reactome: -RNO-193692Reactome: -RNO-205043Reactome: -RNO-3928665Reactome: -RNO-9013507Reactome: -RNO-9017802Reactome: -RNO-9839383 |
Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus Membrane |
Alternative ELISA Names | Presenilin-2 ELISA kitPs-2 Cleaved Into - Presenilin-2 Ntf Subunit - Presenilin-2 Ctf Subunit ELISA kitPsen2 ELISA kitPs2 ELISA kitPsnl2 ELISA kit |
output | |
Information sourced from Uniprot.org