rat Peroxiredoxin 2/PRDX2 protein (Recombinant) (His-Tag) (STJP019208)

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STJP019208
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Short Description :Recombinant-rat Peroxiredoxin 2/PRDX2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol1mM DTT
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:Prdx2
Gene ID:29338
Uniprot ID:PRDX2_RAT
Accession Number:NP_058865
Immunogen:Rat
Immunogen Region:1-198aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMASGNA HIGKPAPDFT GTAVVDGAFK EIKLSDYRGK YVVLFFYPLD FTFVCPTEII AFSDHAEDFR KLGCEVLGVS VDSQFTHLAW INTPRKEGGL GPLNIPLLAD VTKSLSQNYG VLKNDEGIAY RGLFIIDAKG VLRQITVNDL PVGRSVDEAL RLVQAFQYTD EHGEVCPAGW KPGSDTIKPN VDDSKEYFSK HN
Post Translational Modifications The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner. Acetylation increases resistance to transition to high molecular-mass complexes. Deacetylated by HDAC6 which decreases reducing activity.
Function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).
Protein Name Peroxiredoxin-2
Thiol-Specific Antioxidant Protein
Tsa
Thioredoxin Peroxidase 1
Thioredoxin-Dependent Peroxide Reductase 1
Thioredoxin-Dependent Peroxiredoxin 2
Database Links Reactome: R-RNO-3299685
Reactome: -RNO-5628897
Cellular Localisation Cytoplasm
Alternative Protein Names Peroxiredoxin-2 protein
Thiol-Specific Antioxidant Protein protein
Tsa protein
Thioredoxin Peroxidase 1 protein
Thioredoxin-Dependent Peroxide Reductase 1 protein
Thioredoxin-Dependent Peroxiredoxin 2 protein
Prdx2 protein
Tdpx1 protein

Information sourced from Uniprot.org

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