| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | Osm |
| Gene ID: | 289747 |
| Uniprot ID: | ONCM_RAT |
| Immunogen Region: | Lys26-Arg208 |
| Immunogen: | Recombinant Rat Oncostatin-M/OSM Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys26-Arg208) ofRat Oncostatin-M/OSM (Accession #NP_001006962.1) fused with a His tag at the C-terminus. |
| Immunogen Sequence: | KRGCSSSSPKLLSQLKSQAN ITGNTASLLEPYILHQNLNT LTLRAACTEHPVAFPSEDML RQLSKPDFLSTVHATLGRVW HQLGAFRQQFPKIQDFPELE RARQNIQGIRNNVYCMARLL HPPLEIPEPTQADSGTSRPT TTAPGIFQIKIDSCRFLWGY HRFMGSVGRVFEEWGDGSRR SRR |
| Post Translational Modifications | Propeptide processing is not important for receptor binding activity but may be important growth-inhibitory activity. |
| Function | Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. |
| Protein Name | Oncostatin-MOsm |
| Database Links | Reactome: R-RNO-6788467 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Oncostatin-M proteinOsm proteinOsm protein |
Information sourced from Uniprot.org