| Tissue Specificity | The OGDH-containing OGDHC complex is present in the brain and in the heart. |
| Post Translational Modifications | |
| Function | 2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC (Probable). Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST) (Probable). Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids. Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate. Mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. |
| Protein Name | 2-Oxoglutarate Dehydrogenase Complex Component E1E1oOgdc-E1Ogdh-E12-Oxoglutarate Dehydrogenase - MitochondrialAlpha-Ketoglutarate DehydrogenaseAlpha-Kgdh-E1Thiamine DiphosphateThdp-Dependent 2-Oxoglutarate Dehydrogenase |
| Database Links | Reactome: R-RNO-6783984Reactome: -RNO-9837999Reactome: -RNO-9853506 |
| Cellular Localisation | MitochondrionNucleusMainly Localizes In The MitochondrionA Small Fraction Localizes To The NucleusWhere The 2-Oxoglutarate Dehydrogenase Complex Is Required For Histone Succinylation |
| Alternative ELISA Names | 2-Oxoglutarate Dehydrogenase Complex Component E1 ELISA kitE1o ELISA kitOgdc-E1 ELISA kitOgdh-E1 ELISA kit2-Oxoglutarate Dehydrogenase - Mitochondrial ELISA kitAlpha-Ketoglutarate Dehydrogenase ELISA kitAlpha-Kgdh-E1 ELISA kitThiamine Diphosphate ELISA kitThdp-Dependent 2-Oxoglutarate Dehydrogenase ELISA kitOgdh ELISA kitOgdhl ELISA kit |
| output | |
Information sourced from Uniprot.org
