| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. |
| Protein Name | 2'-5'-Oligoadenylate Synthase 1a(2-5'Oligo(A Synthase 1a2-5a Synthase 1a |
| Database Links | |
| Cellular Localisation | CytoplasmMitochondrionNucleusMicrosomeEndoplasmic ReticulumAssociated With Different Subcellular Fractions Such As MitochondrialNuclearAnd Rough/Smooth Microsomal Fractions |
| Alternative ELISA Names | 2'-5'-Oligoadenylate Synthase 1a ELISA kit(2-5'Oligo(A Synthase 1a ELISA kit2-5a Synthase 1a ELISA kitOas1a ELISA kitOas1 ELISA kit |
| output | |
Information sourced from Uniprot.org
