rat Lipocalin-2/NGAL protein (Recombinant) (His-Tag) (STJP019224)

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STJP019224
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-rat Lipocalin-2/NGAL-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in phosphate-Buffered Saline (pH 7.4) containing 20% Glycerol
Concentration: 0.25 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: Lcn2
Gene ID: 170496
Uniprot ID: NGAL_RAT
Immunogen Region: 21-198aa
Accession Number: NP_570097.1
Immunogen: Rat
Immunogen Sequence: QDSTQNL IPAPPLISVP LQPGFWTERF QGRWFVVGLA ANAVQKERQS RFTMYSTIYE LQEDNSYNVT SILVRGQGCR YWIRTFVPSS RPGQFTLGNI HSYPQIQSYD VQVADTDYDQ FAMVFFQKTS ENKQYFKVTL YGRTKGLSDE LKERFVSFAK SLGLKDNNIV FSVPTDQCID N
Tissue Specificity Detected in the ureteric bud in embryonic kidney (at protein level).
Function Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity.limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin. Can also bind siderophores from M.tuberculosis.
Protein Name Neutrophil Gelatinase-Associated Lipocalin
Ngal
Alpha-2-Microglobulin-Related Protein
Alpha-2u Globulin-Related Protein
Lipocalin 24p3
Lipocalin-2
Siderocalin Lcn2
P25
Database Links Reactome: R-RNO-6798695
Reactome: -RNO-6799990
Reactome: -RNO-917937
Cellular Localisation Secreted
Cytoplasmic Granule Lumen
Cytoplasmic Vesicle Lumen
Upon Binding To The Slc22a17 (24p3r) Receptor
It Is Internalized
Releases The Bound Iron In The Acidic Lumen Of Cytoplasmic Vesicles
Alternative Protein Names Neutrophil Gelatinase-Associated Lipocalin protein
Ngal protein
Alpha-2-Microglobulin-Related Protein protein
Alpha-2u Globulin-Related Protein protein
Lipocalin 24p3 protein
Lipocalin-2 protein
Siderocalin Lcn2 protein
P25 protein
Lcn2 protein

Information sourced from Uniprot.org

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