| Applications: | ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 11.5pg/mL |
| Detection Limit: | 31.2-2000pg/mL |
| Short Description: | This IP10 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | Cxcl10 |
| Gene ID: | 245920 |
| Uniprot ID: | CXL10_RAT |
| Sample Type: | serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | In the central nervous system, CXCL10 is predominantly localized to activated neurons. Expressed in both microglia and astrocytes. |
| Post Translational Modifications | |
| Function | Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization. |
| Protein Name | C-X-C Motif Chemokine 10 10 Kda Interferon Gamma-Induced Protein Gamma-Ip10 Ip-10 Interferon-Inducible Protein 10 Protein Mob-1 Small-Inducible Cytokine B10 |
| Database Links | Reactome: R-RNO-380108 Reactome: -RNO-418594 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | C-X-C Motif Chemokine 10 ELISA kit 10 Kda Interferon Gamma-Induced Protein ELISA kit Gamma-Ip10 ELISA kit Ip-10 ELISA kit Interferon-Inducible Protein 10 ELISA kit Protein Mob-1 ELISA kit Small-Inducible Cytokine B10 ELISA kit Cxcl10 ELISA kit Inp10 ELISA kit Mob1 ELISA kit Scyb10 ELISA kit |
| output |
Information sourced from Uniprot.org
