| Host: |
HEK293 cells |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Rat IL-4RA/CD124-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Il4r |
| Gene ID: |
25084 |
| Uniprot ID: |
IL4RA_RAT |
| Immunogen Region: |
Ile26-Arg232 |
| Immunogen: |
Recombinant Rat IL-4RA/CD124 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile26-Arg232) of rat IL-4RA/CD124 (Accession #NP_596871.2) fused with a 6×His tag at the C-terminus. |
| Post Translational Modifications | On IL4 binding, phosphorylated on C-terminal tyrosine residues. |
| Function | Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Isoform 2 (soluble form) inhibits IL4-induced spleen cell proliferation. |
| Protein Name | Interleukin-4 Receptor Subunit AlphaIl-4 Receptor Subunit AlphaIl-4r Subunit AlphaIl-4r-AlphaIl-4raCd Antigen Cd124 |
| Database Links | Reactome: R-RNO-6785807 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Protein Names | Interleukin-4 Receptor Subunit Alpha proteinIl-4 Receptor Subunit Alpha proteinIl-4r Subunit Alpha proteinIl-4r-Alpha proteinIl-4ra proteinCd Antigen Cd124 proteinIl4r proteinIl4ra protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
