Rat IL-4RA/CD124 protein (Recombinant) (C-His) (STJP002790)

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STJP002790
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: <1 EU/Mu g
Gene Symbol: Il4r
Gene ID: 25084
Uniprot ID: IL4RA_RAT
Immunogen Region: Ile26-Arg232
Immunogen: Recombinant Rat IL-4RA/CD124 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile26-Arg232) of rat IL-4RA/CD124 (Accession #NP_596871.2) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: IKVLGDPTCFSDYIRTSTCE WQLDSTVDCSSQLLLDYRLL FEFSENLTCTPKNSADTVCV CQMAIEEPIQADTYWLELWS ERGQLWQGSFKPSDNVKPPA PDNLTLHTNVSNALLLMWSN PYPSNNFLHKGLICMVNISR EDNPAEFKVYNVTYTEPKLS FPVNTLTSGVRYRARVRVLS QSFPGIWSEWSPSITWYNHF QLPLLQR
Post Translational Modifications On IL4 binding, phosphorylated on C-terminal tyrosine residues.
Function Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Isoform 2 (soluble form) inhibits IL4-induced spleen cell proliferation.
Protein Name Interleukin-4 Receptor Subunit Alpha
Il-4 Receptor Subunit Alpha
Il-4r Subunit Alpha
Il-4r-Alpha
Il-4ra
Cd Antigen Cd124
Database Links Reactome: R-RNO-6785807
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Secreted
Alternative Protein Names Interleukin-4 Receptor Subunit Alpha protein
Il-4 Receptor Subunit Alpha protein
Il-4r Subunit Alpha protein
Il-4r-Alpha protein
Il-4ra protein
Cd Antigen Cd124 protein
Il4r protein
Il4ra protein

Information sourced from Uniprot.org

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