| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g |
| Immunoreactivity: | Measured by its ability to inhibit IL-1 alpha-dependent proliferation in D10.G4.1 mouse helper T cells. The ED50 for this effect is 2.62-10.48 ng/mL in the presence of 50 pg/mL of rrIL-1 alpha, corresponding to a specific activity of 9.54× |
| Gene Symbol: | Il1rn |
| Gene ID: | 60582 |
| Uniprot ID: | IL1RA_RAT |
| Immunogen Region: | His27-Gln178 |
| Immunogen: | Recombinant Rat IL-1Ra/IL-1F3/IL-1RN Protein is produced by E. coli expression system. The target protein is expressed with sequence (His27-Gln178) of rat IL-1Ra/IL-1F3/IL-1RN (Accession #NP_071530.1) fused with no additional amino acid. |
| Immunogen Sequence: | CDLPQTHSLGNRRALILLAQ MGRISHFSCLKDRYDFGFPQ EVFDGNQFQKAQAISAFHEM IQQTFNLFSTKDSSAAWDET LLDKFYIELFQQLNDLEACV TQEVGVEEIALMNEDSILAV RKYFQRITLYLMGKKYSPCA WEVVRAEIMRSFSFSTNLQK GLRRKD |
| Function | Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens. |
| Protein Name | Interleukin-1 Receptor Antagonist ProteinIl-1rnIl-1raIrapIl1 Inhibitor |
| Database Links | Reactome: R-RNO-9020702 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Interleukin-1 Receptor Antagonist Protein proteinIl-1rn proteinIl-1ra proteinIrap proteinIl1 Inhibitor proteinIl1rn proteinIl-1ra protein |
Information sourced from Uniprot.org