| Applications: | ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.053ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description: | This IDO Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat serum, plasma, tissue homogenates or other biological fluids.. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | Ido1 |
| Gene ID: | 66029 |
| Uniprot ID: | I23O1_RAT |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity. Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection. |
| Protein Name | Indoleamine 2 -3-Dioxygenase 1 Ido-1 Indoleamine-Pyrrole 2 -3-Dioxygenase |
| Database Links | Reactome: R-RNO-71240 |
| Cellular Localisation | Cytoplasm Cytosol |
| Alternative ELISA Names | Indoleamine 2 -3-Dioxygenase 1 ELISA kit Ido-1 ELISA kit Indoleamine-Pyrrole 2 -3-Dioxygenase ELISA kit Ido1 ELISA kit Ido ELISA kit Indo ELISA kit |
| output |
Information sourced from Uniprot.org
